2018年7月10日 星期二
 
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马博

 

马博,男,副教授,毕业于中国药科大学 药物代谢动力学博士

.主讲课程

生物药剂学与药物动力学;生理药理学;药理学

.研究领域

主要研究方向:代谢组学,药物代谢动力学,药理学,体内药物分析。

主要研究领域包括:

1. 基于代谢组学的疾病生物标志物探索和药物作用机理研究

本实验室自从2006年至今,完成代谢组学平台的建设和方法的应用,开展了高脂血症、高血压、肥胖、绝经后骨质疏松症、糖尿病肾病、胃癌、卵巢癌、少弱精子症等疾病生物标志物探索、发现和确证;并将此技术应用于银杏叶提取物,果糖二磷酸锶,冬凌草甲素等药效学评价和作用机制的研究,已发表SCI文章数十篇。

2. 药物体内外ADME过程的研究与评价技术平台;

2.1 建立了LC-MS/MS, GC-MS, HPLC等现代分析仪器的体内药物检测及验证技术体系。在此基础上,两年内完成了愈美缓释片、非诺贝特胆碱盐缓释片、酮咯酸氨丁三醇喷雾剂,多潘立酮,尼美舒利颗粒剂,硝苯地平缓释片,头孢呋辛酯,阿仑膦酸钠等药物的临床前和临床生物等效性评价及注册;

2.2 成功复制了CYP450微粒体温孵, 离体肝灌流, Caco-2细胞模型等技术平台,开展多个新化合物及制剂的体内外吸收动力学,代谢物鉴定,代谢稳定性,代谢途径,药物-药物相互作用及其细胞内转运机制的研究;

2.3 中药多组分的体内ADME和药效物质基础的研究,已初步开展了刺五加,冬凌草,蛇床子,菟丝子等,发表多篇SCI论文。

.主要科研业绩

3.1主持的国家及省部级课题共6

1. 国家自然科学基金青年基金项目:

3. 江苏省自然科学基金青年基金项目

2. 国家博士后基金面上项目(一等资助)

4. 高等学校博士学科点专项科研基金资助(新教师类)

5. 江苏省高校自然科学研究面上项目

6. 江苏省博士后基金资助

3.2参与纵向课题

参与国家自然科学基金5项;江苏省临床专项1项;江苏省青年基金1项;江苏省六大人才高峰课题1项。

3.3 参与横向课题

参与完成:蒺藜皂苷、关白附等中药多组分的临床前药物代谢动力学研究;愈美缓释片、非诺贝特胆碱盐缓释片、琥珀酸美托洛尔,酮咯酸氨丁三醇喷雾剂等临床前生物利用度研究;多潘立酮,尼美舒利,硝苯地平缓释片,头孢呋辛酯,阿仑膦酸钠等临床生物等效性实验;阿奇霉素,林可霉素,氨曲南等多种注射剂的局部毒性实验。

3.4代表性成果

3.4.1 代表性文章

[1] Ma B, Liu J, Zhang Q*, Ying H, A J, Sun J. Metabolomic Profiles Delineate Signature

Metabolic Shifts during Estrogen Deficiency-Induced Bone Loss in Rat by GC-TOF/MS. PLOS

ONE, 2013,8(2):e54965.IF: 4.092

[2] Ma B, Zhang Q, Wang G*, Wu Z, Shaw JP, Hu Y. Synthesis and pharmacokinetics of

strontium fructose 1,6-diphosphate (Sr-FDP) as a potential anti-osteoporosis agent in intact and

ovariectomized rats. J Inorg Biochem, 2011,105(4):563-8. IF: 3.354

[3] Ma B, Shang X, Zhang Q*, Li J, Liu Y, Cao X. Rapid analysis of tadalafil in human

blood plasma and seminal plasma by liquid chromatography/tandem mass spectrometry. J Pharm

Biomed Anal, 2013,77C:149-157. IF: 2.967

[4] Ma B, Zhang Q, Liu Y, Li J, Xu Q, Li X*. Simultaneous determination of Eleutheroside B and

Eleutheroside E in rat plasma by high performance liquid chromatography-electrospray ionization

mass spectrometry and its application in a pharmacokinetic study. J Chromatogr B Analyt Technol

Biomed Life Sci, 2013,917-918:84-92.IF: 2.888

[5] Ma B1, Liu Y1, Zhang Q*, Ying H, Li J, Xu Q. Development and validation of a sensitive

liquid chromatography/tandem mass spectrometry method for the determination of raddeanin A in

rat plasma and its application to a pharmacokinetic study. J Chromatogr B Analyt Technol Biomed

Life Sci, 2013,912:16-23.(共同第一作者, IF:2.888

[6] Bo Ma, Xiaotian Li, Jing Li, Qi Zhang*, Yinhui Liu, Xiaojing Yang. Quantitative analysis of

tenuifolin concentrations in rat plasma and tissue using LCMS/MS: application to

pharmacokinetic and tissue distribution study. Journal of Pharmaceutical and Biomedical Analysis,

2014, 88(22):191-200. IF: 2.967

[7] Bo Ma, Xiaotian Li, Qi Zhang*, Di Wu, Guangji Wang, Jiye A, Jianguo Sun, Jing Li, Yinhui Liu, Yonglu Wang, Hanjie Ying. Metabonomic profiling in studying anti-osteoporosis effects of strontium fructose 1,6-diphosphate on estrogen deficiency-induced osteoporosis in rats by GC/TOF-MS. European Journal of Pharmacology, 2013,718(1): 524532.(IF:2.592)

[8] Ma B, Zhang Q*, Wu D, Wang YL, Hu YY, Cheng YP, Yang ZD, Zheng YY, Ying HJ.

Strontium fructose 1,6-diphosphate prevents bone loss in a rat model of postmenopausal

osteoporosis via the OPG/RANKL/RANK pathway. Acta Pharmacol Sin, 2012,33(4):479-89

IF:2.354

[9] Ma B, Zhang Q, Wang GJ*, A JY, Wu D, Liu Y. GC-TOF/MS-based metabolomic profiling of

estrogen deficiency-induced obesity in ovariectomized rats. Acta Pharmacol Sin, 2011,32(2):270

IF: 2.354

[10] Ma B, Wang Y, Zhang Q*, Liu Y, Li J, Xu Q. Simultaneous Determination of Oridonin,

Ponicidin and Rosmarinic Acid from Herba Isodi Rubescentis Extract by LC-MS-MS in Rat

Plasma. J Chromatogr Sci, 2013.Available online 2013 Jan IF: 0.884

[11] Ma B, Zhang Q*. Recent Advances of the Traditional Chinese Medicines on the

Pharmacological Management of Osteoporosis. The AAPS journalIF: 5.086

[12]Lili Ren1, Bo Ma1, Qi Zhang, Guoguang Chen, Ping Wei*. Quantitative determination of Glaucocalyxin A in rat plasma by LC-MS/MS. Analytical Methods (共同第一作者IF:1.855)

[13] Xuejun Shang, Juan Liu, Qiuyu Xu, Qi Zhang*, Bo Ma, YongLu Wang. Expression and distribution of Attractin related changes in the different developmental stages of rats testis. International Journal of Molecular Medicine. Accept, IF:1.957

[14] Cao XM, Rui JZ, Wang YL, Li JH*, Ma B, Yang ZD. Simultaneous Determination of Isoniazid and Acetylisoniazid in Human Plasma by Hydrophilic Interaction Liquid Chromatography Tandem Mass Spectrometry and Its Application to a Pharmacokinetics Related to N-Acetyltransferase2 Genetic Polymorphism. Analytical Letters, 2012,45(15): 2125-2135. IF:1.016

[15] Zhang Q, Wang G*, A J, Ma B, Dua Y, Zhu L. Metabonomic profiling of diet-induced hyperlipidaemia in a rat model. Biomarkers, 2010,15(3):205-16. IF: 1.879

[16] Xu QY, Liu YH, Zhang Q, Ma B, Yang ZD, Liu L, et al. Metabolomic analysis of simvastatin and fenofibrate intervention in high-lipid diet-induced hyperlipidemia rats. Acta Pharmacol Sin 201435:1265-73.

[17] Li J, Ma B, Zhang Q, Yang X, Sun J, Tang B, et al. Simultaneous determination of osthole, bergapten and isopimpinellin in rat plasma and tissues by liquid chromatography-tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci 2014970:77-85.

3.4.2 英文专著

Hanjie Ying, Qi Zhang, Bo Ma. The Effects of Strontium on Physiology, Pharmacology and Toxicity of the Human pp. 1-26The chapter 1),《Strontium: Chemical Properties, Applications and Health Effects》,Nova publishersPages: 180, 7x10 - (NBC-R), Pub. Date: 2013- January.

获奖情况

2013年南京工业大学优秀教学成果奖(二等奖)

第六届南京工业大学青年教师授课竞赛(三等奖)

第六届南京工业大学多媒体教学课件暨省优秀课件遴选建设竞赛(三等奖)

2014年本科优秀论文指导教师




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