2018年7月9日 星期一
 
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张琪

 

姓名:张  琪

职称:教授,博士生导师

职务:万博ManBeTx投注 副院长;

   药动药效研究与评价中心主任

学术兼职:

江苏省高校医药教育研究会副理事长

中国药学会应用药理学会常务理事

江苏省药理学会常务理事

药学核心期刊《中国临床药理学与治疗学》、《中华男科学杂志》编委

江苏省食品药品监督管理局新药审评与现场核查专家

教育简历

美国纽约州立大学布法罗分校(State University of New York at Buffalo)博士后;

中国药科大学药理学博士。

研究领域:药理学、药物动力学、代谢组学。

在基础研究领域着重于各类新药的临床前与临床的药物动力学、药效学筛选、药理学机制靶点、药效-药动学模型研究,以及骨质疏松症、高脂血症等重大疾病的代谢组学研究。尤其是代谢组学方法学及其应用的研究成果处于国内外前列。

近年来承担国家自然科学基金面上项目5项(主持3项,联合单位负责人2项);“十三五”国家重大新药创制专项1项;国家973预研项目1项;国际合作项目2项(美国纽约州立大学、美国FDA-马里兰大学);江苏省人才基金1项(抗骨质疏松一类新药的临床前研究);江苏省临床医学专项1项(骨质疏松生物标记物研究);参与国家973、省部科研项目8项。申请专利8项(3项授权)。发表学术文章约80篇(56篇被SCI收录);参与编写英文论著1部,中文著作、化工辞典各1部。

主持建立了“南京工业大学 药动药效研究与评价中心”,中心拥有药物分析、药效评价、分子生物学、细胞培养、动物实验等先进技术平台,按照国家食品药品监督管理局颁布的“药物临床试验生物样本分析实验室管理指南”的要求进行建设、管理和运行。有资质从事新药药学、临床前药物动力学、药理学以及临床药物动力学研究(一致性评价与生物等效性实验等)与新药报批工作。

近年来,与美国FDA-马里兰大学、美国纽约州立大学、美国费城儿童医院、美国爱荷华大学、新西兰奥克兰大学等国外高校院所,在代谢组学、PK-PD模型等领域开展国际课题合作。

与中国军事科学院、中国医学科学院、上海第二军医大学、上海华山医院、南京军区总院、山东鲁抗集团、南京白敬宇制药公司等几十家医药科研、企业单位合作研发,主持了碱性成纤维细胞生长因子、黄芪甲苷、磷酸二果糖锶等一类新药的药理学、药动学研究及Etanercept、银杏提取物、硝苯地平缓释片、阿斯匹林缓释片、氢可酮-氯苯那敏缓释胶囊等50多种新药的药理学、药物动力学、生物等效性研究,新药资料全部通过省局现场核查。

所获荣誉:

江苏省“333高层次人才培养工程”培养对象

江苏省“六大人才高峰”培养对象

南京市“321”领军型科技创业人才

讲授课程:

药理学、药物动力学(本科生课程);现代药理学(研究生课程)

科研成果:

参与编写的中英文论著:

英文论著:《Strontium: Chemical Properties, Applications and Health Effects》一书中的第一章节“The Effects of Strontium on Physiology, Pharmacology and Toxicity of the Human” 出版社:NOVA Publishers   出版日期:2013年,ISBN:978-1-62257-631-9

中文论著:《10000个科学难题(医学卷)》, “药动学-药效学结合模型—连接体内药物浓度与药效关系的桥梁”,科学出版社,2011年8月正式出版,P955-958。 “十一五”国家重点图书出版规划项目。

辞典:《化工辞典(第五版)》,化学工业出版社,2014年5月

近年来以通讯作者发表的SCI代表性文章:

[1] DiketopyrrolopyrroleTriphenylamine Organic Nanoparticles as Multifunctional Reagents for Photoacoustic Imaging-Guided Photodynamic/Photothermal Synergistic Tumor Therapy [J]. ACS Nano, 2017, 11 (1): 10541063  

[2] Small-molecule diketopyrrolopyrrole-based therapeutic nanoparticles for photoacoustic imaging-guided photothermal therapy [J]. Nano Research, 2017, 10 (3): 794-801

[3] Aza-Bodipy Photosensitizer for Photoacoustic and Photothermal Imaging Guided Dual Modal Cancer Phototherapy [J]. Journal of Materials Chemistry B, 2017, 5(8):1566-1573.

[4]Synthesis and preclinical pharmacokinetic study of DHA-10, a novel potential antifungal pogostone analogue [J]. Journal of Pharmacy and Pharmacology, 2017, 69 (9): 1084-1090

[5]Metabonomic analysis of fatty acids in seminal plasma between healthy and asthenozoospermic men based on gas chromatography mass spectrometry [J]. Andrologia, 2017, 49 (9): e12744.

[6] Tumor-targeting, enzyme-activated nanoparticles for simultaneous cancer diagnosis and photodynamic therapy [J]. Journal of Materials Chemistry B, 2016, 4(1): 113-120.

[7] Bromo-substituted diketopyrrolopyrrole derivative with specific targeting and high efficiency for photodynamic therapy [J]. ACS applied materials & interfaces, 2016, 8(17): 10737-10742.

[8] Association between the metabolome and bone mineral density in pre-and post-menopausal Chinese women using GC-MS [J]. Molecular BioSystems, 2016, 12(7): 2265-2275

[9] A ThienylSubstituted Diketopyrrolopyrrole Derivative with Efficient Reactive Oxygen Species Generation for Photodynamic Therapy [J]. ChemPlusChem, 2016, 81(6): 515-520.

[10] Diketopyrrolopyrrole Derivatives Grafting Hyaluronic Acid for Targeted Photodynamic Therapy [J]. ChemistrySelect, 2016, 1(12): 3071-3074.

[11] Wnt/β-catenin signaling plays an important role in the protective effects of FDP-Sr against oxidative stress induced apoptosis in MC3T3-E1 cell [J]. Bioorganic & Medicinal Chemistry Letters, 2016, 26(19): 4720-4723. 

[12] Triptolide disrupts fatty acids and peroxisome proliferator-activated receptor (PPAR) levels in male mice testes followed by testicular injury: a GCMS based metabolomics study [J]. Toxicology, 2015, 336: 84-95.

[13] Strontium fructose 1, 6diphosphate alleviate cyclophosphamideinduced oligozoospermia by improving antioxidant and inhibiting testicular apoptosis via FAS/FASL pathway [J]. Andrologia, 2015, 47(9): 995-1003. 

[14]Pharmacokinetics and tissue distribution of Aucubin, Ajugol and Catalpol in rats using a validated simultaneous LC-ESI-MS/MS assay.[J]. Journal of Chromatography B, 2015, 1002:245-253.

[15] A pre-clinical pharmacokinetic study in rats of three naturally occurring iridoid glycosides, Picroside-I, II and III, using a validated simultaneous HPLCMS/MS assay[J]. Journal of Chromatography B, 2015, 993: 47-59.

[16] Quantitative analysis of tenuifolin concentrations in rat plasma and tissue using LC-MS/MS: Application to pharmacokinetic and tissue distribution study [J]. Journal of pharmaceutical and biomedical analysis, 2014, 88: 191-200.

[17] Simultaneous determination of osthole, bergapten and isopimpinellin in rat plasma and tissues by liquid chromatographytandem mass spectrometry [J]. Journal of Chromatography B, 2014, 970: 77-85.

[18] Metabolomic analysis of simvastatin and fenofibrate intervention in high-lipid diet-induced hyperlipidemia rats [J]. Acta Pharmacologica Sinica, 2014, 35(10): 1265-1273.

[19] Comparative pharmacokinetics with single substances and Semen Cuscutae extract after oral administration and intravenous administration Semen Cuscutae extract and single hyperoside and astragalin to rats [J]. Analytical Methods, 2014, 6(18): 7250-7259. 

[20] Metabolomic profiles delineate signature metabolic shifts during estrogen deficiency-induced bone loss in rat by GC-TOF/MS [J]. PLoS One, 2013, 8(2): e54965.

[21] Simultaneous determination of Eleutheroside B and Eleutheroside E in rat plasma by high performance liquid chromatographyelectrospray ionization mass spectrometry and its application in a pharmacokinetic study [J]. Journal of Chromatography B, 2013, 917: 84-92.

[22]Rapid analysis of tadalafil in human blood plasma and seminal plasma by liquid chromatography/tandem mass spectrometry [J]. Journal of pharmaceutical and biomedical analysis, 2013, 77: 149-157.

[23] Simultaneous Determination of Oridonin, Ponicidin and Rosmarinic Acid from Herba Isodi Rubescentis Extract by LCMS-MS in Rat Plasma [J]. Journal of chromatographic science, 2013, 51(10): 910-918.

[24] Development and validation of a sensitive liquid chromatography/tandem mass spectrometry method for the determination of raddeanin A in rat plasma and its application to a pharmacokinetic study [J]. Journal of Chromatography B, 2013, 912: 16-23.

[25] Changes in expression and distribution of attractin in the testes of rats at different developmental stages [J]. International journal of molecular medicine, 2013, 32(3): 599-606. 

[26] Metabonomic profiling in studying anti-osteoporosis effects of strontium fructose 1, 6-diphosphate on estrogen deficiency-induced osteoporosis in rats by GC/TOF-MS [J]. European journal of pharmacology, 2013, 718(1): 524-532.

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电子邮箱:zhangqi@njtech.edu.cn




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