2018年7月9日 星期一
 
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Jonathan B. Baell

PhD, Professor

博士,教授,博士生导师,国家千人计划获得者。

教育背景 & 奖项

Fellowship, 2012-2016: NHMRC Principal Research Fellowship, NHMRC, Australia

Award, August 2004: National Biota Award for Medicinal Chemistry, Royal Australian Chemical Institute, Australia

Ph.D., August 1992: University of Melbourne

B.Sc., October 1986: University of Tasmania

研究领域

Molecular design

Peptidomimetics

Small molecule screening libraries and chemoinformatics

Hit-to-lead and lead optimisation medicinal chemistry

Drug discovery in infectious disease (particularly neglected diseases including malaria) and epigenetic modulation associated with cancer

Pre-clinical development of new drug candidates

工作经历

Employer

Job Title

Role

Type

From

To

Current?

Nanjing Tech

University

Professor

Medicinal Chemistry

Full time

March2017-

 

Yes

Monash University

Professor;

Larkins Fellow; Principal Research Scientist;

NHMRC Senior Research Fellow

Medicinal Chemistry

Full time

April 2012-

 

Yes

Walter and Eliza Hall Institute of Medical Research

Special Fellow

Laboratory Head Medicinal Chemistry

Full time

Jan 2001-

Apr 2012

No

Biomolecular Research Institute

Senior Research Scientist

Design and Discovery of Novel Therapeutics

Full time

Aug 1996

December 2000

No

CSIRO (AHRL, Parkville)

Senior Research Scientist

Project Leader for Research into Toxicants and Discovery of New Treatments

Full time

Mar 1994

July 1996

No

CSIRO (DAH, Sydney)

Research Scientist

Project Leader for Design and Discovery of More Efficacious Anthelmintics

Full time

Mar 1992

Feb 1994

No

CSIRO (DAH,Sydney)

Research Assistant

Design and Discovery of More Efficacious Anthelmintics

Full time

May 1991

Feb 1992

No

University of Melbourne

Research Assistant

System Administrator and Computer-Aided Drug Design

Part time

April 1990

April 1991

No

代表研究成果

1.  Baell J & Walters MA. Chemical con artists foil drug discovery. Nature 513 (2014) 481-483.

2.  Baell JB, et al. Structure-based design and development of functionalized mercaptoguanine derivatives as inhibitors of the folate biosynthesis pathway enzyme 6-Hydroxymethyl-7,8-dihydropterin pyrophosphokinase from Staphylococcus aureus. J. Med. Chem. 57 (2014) 9612-9626.

3.  Baell JB*, et al. Pyridyl benzamides as a novel class of potent inhibitors for the kinetoplastid Trypanosoma brucei. J. Med. Chem. 57 (2014) 6393-6402.

4.  Baell JB, et al. Christopoulos A, Shaw DE. Structural basis for modulation of a GPCR by allosteric drugs. Nature 503 (2013) 295-299.

5.  Baell JB*, et al. De-Novo Designed Library of Benzoylureas as Inhibitors of BCL-XL: Synthesis, Structural and Biochemical Characterization. J. Med. Chem. 57 (2014) 1323-1343.

6.  Baell JB*, et al. Truncated Latrunculins as Actin Inhibitors Targeting Plasmodium falciparum Motility and Host Cell Invasion. J. Med. Chem. 59 (2016) 10994-11005.

7.  Baell JB*, et al. Hit-to-Lead Optimization of a Novel Class of potent, Broad-Spectrum Trypanosomacides. J. Med. Chem. 59 (2016) 9686-9720.

 




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